研究亮點

1.       Chen SY, Chiu LY, Maa MC, Wang JS, Chien CL, Lin WW. zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation. Autophagy. 2011; 7(2): 217-28.

2.       Tseng KW, Peng ML, Wen YC, Liu KJ and Chien CL*. Neuronal degeneration in autonomic nervous system of dystonia musculorum mice. J Biomed Sci. 2011; 18:9.

3.       Huang HP, Chen PH, Hwu WL, Chuang CY, Chien YH, Stone L, Chien CL, Li LT, Chiang SC, Chen HF, Ho HN, Chen CH, Kuo HC*. Human Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification. Hum Mol Genet. 2011; 20(24): 4851-64.

4.       Lee WC, Chen YY, Kan D, Chien CL*. A neuronal death model: Overexpression of neuronal intermediate filament protein peripherin in PC12 cells. J Biomed Sci. 2012; 19:8. doi: 10.1186/1423-0127-19-8.

5.       Lee WC, Kan D, Chen YY, Han SK, Lu KS, Chien CL*. Suppression of extensive neurofilament phosphorylation rescues α-internexin/peripherin-overexpressing PC12 cells from neuronal cell death. PLoS One. 2012; 7(8): e43883. doi:10.1371.

6.       Chen YT, Tsai MS, Yang TL, Ku AT, Huang KH, Huang CY, Chou FJ, Fan HH, Hong JB, Yen ST, Wang WL, Lin CC, Hsu YC, Su KY, Su IC, Jang CW, Behringer RR, Favaro R, Nicolis SK, Chien CL, Lin SW*, Yu IS*. R26R-GR: A cre-activable dual fluorescent protein reporter mouse. PLoS One. 2012; 7(9): e46171.

7.       Chen YL, Chang MC, Chen CA, Lin HW, Cheng WF*, Chien CL*. Depletion of regulatory T lymphocytes reverses the imbalance between pro- and anti-tumor immunities via enhancing antigen-specific T cell immune responses. PLoS One. 2012; 7: e47190.

8.       Chen SJ, Tsai JC, Lin CY, Chang CK, Tseng TH, Chien CL*. Brain-derived neurotrophic factor-transfected and nontransfected 3T3 fibroblasts enhance migratory neuroblasts and functional restoration in mice with intracerebral hemorrhage. J Neuropathol Exp Neurol. 2012; 71:1123-1136.

9.       Peng ML, Tsai CY, Chien CL, Hsiao JCJ, Huang SY, Lee CJ, Lin HY, Wen YC and Tseng, KW*. The influence of low-powered family LED lighting on eyes in mice experimental model. Life Science Journal. 2012; 9:477-482.

10.    Liu CH, and Chien CL*. Molecular cloning and characterization of chicken neuronal intermediate filament protein α-internexin. J Comp Neurol. 2013; 521:2147-64.

11.    Liu CH, Wang IJ, Wei FD, Chien CL*. Neuronal intermediate filament α- internexin is expressed by neuronal lineages in the developing chicken retina. Exp Eye Res. 2013; 110:18-25.

12.    Wang NK, Lai CC, Liu CH, Yeh LK, Chou CL, Kong J, Nagasaki T, Tsang S, and Chien CL*. Origin of fundus hyperautofluorescent (AF) spots, and their role in retinal degeneration in a mouse model of Goldmann-Favre Syndrome. Dis Model Mech. 2013; 6:1113-22. doi: 10.1242/dmm.012112.

13.    Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL* and Kuo HC*. LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. Nucleic Acids Res. 2013; 41:7753-7770.

14.    Shen WC, Liang CJ, Wu VC, Wang SH, Young GH, Lai IR, Chien CL, Wang SM, Wu KD, Chen YL. Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression. Stem Cells Dev. 2013; 22:1408-1418.

15.    Chen YL, Cheng WF, Chang MC, Lin HW, Huang CT, Chien CL* and Chen CA*. Interferon-gamma in ascites could be a predictive biomarker of outcome in ovarian carcinoma. Gynecol Oncol. 2013; 131:63-68.

16.    Chen HF, Jan PS, Kuo HC, Wu FC, Lan CW, Huang MC, Chien CL, Ho HN*. Granulosa cells and retinoic acid co-treatment enrich potential germ cells from manually selected Oct4-EGFP expressing human embryonic stem cells.  Reprod Biomed Online. 2014; 05:009. doi: 10.1016/j.rbmo.

17.    Hong JH, Lee WC, Hsu YM, Liang HJ, Wan CH, Chien CL*, Lin CY*. Characterization of the biochemical effects of naphthalene on the mouse respiratory system using NMR-based metabolomics. J Appl Toxicol. 2014; 34(12): 1379-1388

18.    Hou PS, Huang WC, Chiang W, Lin WC, Chien CL*. Impaired neural differentiation potency by retinoic acid receptor-α pathway defect in induced puripotent stem cells. Cell Reprogram. 2014;16: 467-476. doi: 10.1089/cell.2014.0029.

19.    Hong JB, Chou FJ, Ku Amy T., Fan HH, Lee TL, Huang YH, Yang TL , Su IC, Yu IS, Lin SW, Chien CL, Ho HN, Chen YT*. A nucleolus-predominant piggybac transposase, NP-mPB, Mediates elevated transposition efficiency in mammalian cells. PLoS One. 2014; 9(2): e89396

20.    Chao CC, Kan D, Lu KS, Chien CL*. The role of microRNA-30c in the self-renewal and differentiation of C6 glioma cells. Stem Cell Res. 2015; 14(2): 211-23. doi: 10.1016/j.scr.2015.01.008.

21.    Li YC, Chen SJ and Chien CL*. Erythropoietin produced by genetic-modified NIH/3T3 fibroblasts enhances the survival of degenerating neurons. Brain Behav. 2015; 5(8) (Cover), doi: 10.1002/brb3.356.

22.    Chao CC, Kan D, Lo TH, Lu KS, Chien CL*. Induction of neural differentiation in rat c6 glioma cells with taxol. Brain Behav. 2015; 5(12) (Cover), doi: 10.1002/brb3.414

23.    Liao ML, Peng WH, Kan D, Chien CL*. Developmental Pattern of the neuronal intermediated filament inaa in the zebrafish retina . J Comp Neurol. 2016; 524(18): 3810-3826. doi: 10.1002/cne.24033.

24.    Lee WD, Wang KC, Tsai, YF, Chou PC, Tsai LK, Chien CL. Subarachnoid hemorrhage promotes proliferation, differentiation, and migration of neural stem cells via BDNF upregulation. PLoS one. 2016 (in press)

 

25.    Numpaisal PO, Rothrauff BB, Gottardi R, Chien CL, Tuan RS. Rapidly dissociated autologous meniscus tissue enhances meniscus healing: An in vitro study. Connect Tissue Res. 2016; 11:1-11. [Epub ahead of print.]