sregulation of the DNA damage response and p53 activation is a central mechanism by which normal and malignant hematopoietic cells survive genotoxic stresses such as chemotherapy and radiation.  Our lab studies how PPM1D, a gene that is recurrently activated in clonal hematopoiesis and myeloid neoplasia, regulates normal hematopoietic stem cell function and how PPM1D contributes to the development of therapy resistance in myelodysplastic syndrome and acute myeloid leukemia.  Using a combination of human genetics, mouse models, and engineered cell systems, we have found that PPM1D is a central regulator of hematopoietic cell fitness, particularly in the context of genotoxic stress, and is a target in myeloid malignancies.  These biological insights have led to a drug discovery effort to target PPM1D and other regulators of the DNA damage response.

一、主辦單位：國立臺灣大學基因體暨精準醫學研究中心／協辦單位：社團法人台灣微生物菌相與精準健康學會

二、講座時間：112年08月25日（五）上午11:00至12:00。

三、講　　者：哈佛大學Dr. Peter Grant Miller（現職：Assistant Professor of Medicine, Harvard Medical School, Massachusetts General Hospital Center for Cancer Research）

四、參加對象：台大及台大醫院之學生及教職員。

五、講座地點：台北市中正區仁愛路一段1號　國立臺灣大學醫學院 304 講堂。

六、報名方式：至https://forms.gle/ZGkfN59U4iKSru5v5填具相關資料即完成報名，講座當天請出示有效身分證件供現場工作人員核對。

七、報名截止日：即日起至112年08月24日（四）中午12點止。（若報名人數已達講堂座位上限，將提早關閉表單）

八、講座費用：免費，歡迎多多推廣、共襄盛舉。

九、注意事項：講座全程請勿錄影、錄音，講堂內亦禁止飲食。

社團法人台灣微生物菌相與精準健康學會

Taiwan Association of Microbiome & Precision Health

秘書處：詹彩蓮 Polly Chan／游舒婷 Judy Yu

電話：(02)2312-3456 #288685

傳真：(02)3322-4179

E-mail：tambph@gmail.com